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Carlos Castro

  • Assistant Professor, Mechanical & Aerospace Engr
  • 201 W 19th Ave
    E328 Scott Lab
    Columbus, OH 43210
  • 614-292-2662

About

Research interests include:

  • Utilize engineering approaches combined with nanotechnology and biophysics experimental tools
  • Characterize and model the physical properties and behaviors of complex biological systems
  • Goal to establish an array of functional DNA nanotechnology-based tools
  • Goal to reverse engineer the design of biological systems that exhibit remarkable mechanical properties

Honors

  • 2014-2019

    National Science Foundation Career Award. .

  • 2015

    Michael J Moran Award for Teaching Excellence. .

  • 2013

    Pi Tau Sigma Above and Beyond Award. .

  • 2009-2011

    Alexander von Humboldt Post-doctoral Fellow. .

  • 2008

    Outstanding research award. .

  • 2005-2006

    Presidential Fellowship. .

Journal Articles

2016

  • 2016, "DNA Origami: Folded DNA-Nanodevices That Can Direct and Interpret Cell Behavior.." Adv Mater 28, no. 27,
  • 2016, "Daunorubicin-Loaded DNA Origami Nanostructures Circumvent Drug-Resistance Mechanisms in a Leukemia Model." SMALL 12, no. 3,
  • Le, J.V., Luo, Y., Darcy, M., Lucas, C.R., Goodwin, M., Poirier, M.G., Castro, C.E., 2016, Probing nucleosome stability with a DNA origami nanocalipers. ACS Nano 10, no. 7, 7073-7084 - 7073-7084.
  • 2016, "PSEUDO-RIGID-BODY MODELS OF COMPLIANT DNA ORIGAMI MECHANISMS." INTERNATIONAL DESIGN ENGINEERING TECHNICAL CONFERENCES AND COMPUTERS AND INFORMATION IN ENGINEERING CONFERENCE, 2015, VOL 5B
  • 2016, "Directing folding pathways for multi-component DNA origami nanostructures with complex topology." NEW JOURNAL OF PHYSICS 18,
  • 2016, "Probing Nucleosome Stability with a DNA Origami Nanocaliper." ACS Nano 10, no. 7,

2015

2014

  • 2014, "DNA translocation through short nanofluidic channels under asymmetric pulsed electric field." BIOMICROFLUIDICS 8, no. 2,
  • 2014, "DNA Origami Compliant Nanostructures with Tunable Mechanical Properties." ACS NANO 8, no. 1,
  • 2014, "The exoskeletal structure and tensile loading behavior of an ant neck joint.." J Biomech 47, no. 2,

2013

  • 2013, "DNA translocation dynamics through short nanochannels under asymmetric pulsed electric field." 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013 2,
  • Wu,Yun; Kwak,Kwang,Joo; Agarwal,Kitty; Marras,Alexander*; Wang,Chao; Mao,Yicheng; Huang,Xiaomeng; Ma,Junyu; Yu,Bo; Lee,Robert; Vachani,Anil; Marcucci,Guido; Byrd,John,C; Muthusamy,Natarajan; Otterson,Gregory; Huang,Kun; Castro,Carlos,E; Paulaitis,Michael; Nana-Sinkam,Serge,P; Lee,L,James, 2013, "Detection of Extracellular RNAs in Cancer and Viral Infection via Tethered Cationic Lipoplex Nanoparticles Containing Molecular Beacons." Analytical Chemistry 85, no. 23, 11265-11274 - 11265-11274.

2011

  • 2011, "Use of an optical trap for study of host-pathogen interactions for dynamic live cell imaging.." J Vis Exp no. 53,
  • 2011, "DNA origami-based nanoribbons: assembly, length distribution, and twist.." Nanotechnology 22, no. 27,
  • 2011, "A primer to scaffolded DNA origami.." Nat Methods 8, no. 3,
  • 2011, "Physical properties of polymorphic yeast prion amyloid fibers.." Biophys J 101, no. 2,
  • Wang,Lifeng; Castro,Carlos,E; Boyce,Mary,C, 2011, "Growth strain-induced wrinkled membrane morphology of white blood cells." Soft Matter 7, no. 24, 11319-11324 - 11319-11324.

2010

  • 2010, "Control and manipulation of pathogens with an optical trap for live cell imaging of intercellular interactions.." PLoS One 5, no. 12,
  • 2010, "Optical trapping with high forces reveals unexpected behaviors of prion fibrils.." Nat Struct Mol Biol 17, no. 12,
  • Lee,Hyungsuk; Castro,Carlos,E; Shin,Yongdae; Kamm,Roger,D; Lang,Matthew,J, 2010, "Active Stochastic Microrheology using Optical Tweezers." Biophysical Journal 98, no. 3, 592A-592A - 592A-592A.

2009

  • 2009, "The alphabeta T cell receptor is an anisotropic mechanosensor.." J Biol Chem 284, no. 45,

2008

  • 2008, "Use of data envelopment analysis and clustering in multiple criteria optimization." INTELLIGENT DATA ANALYSIS 12, no. 1,

2007

  • 2007, "Multiple criteria optimization with variability considerations in injection molding." POLYMER ENGINEERING AND SCIENCE 47, no. 4,
  • Brau,R,R; Ferrer,J,M; LEE,H; Castro,C,E; Tam,B,K; Tarsa,P,B; Matsudaira,P; Boyce,M,C; Kamm,R,D; Lang,M,J, 2007, "Passive and active microrheology with optical tweezers." Journal of Optics A-Pure and Applied Optics 9, no. 8, S103-S112 - S103-S112.

2005

  • 2005, "Simultaneous optimization of mold design and processing conditions in injection molding." JOURNAL OF POLYMER ENGINEERING 25, no. 6,

2003

Presentations

  • "Mechanical design of DNA nanostructures."
  • "DNA origami tools for chromatin for the study of chromatin structure and dynamics." 2015,
  • "Mechanical Design of DNA Nanostructures for Physical Measurements." 2015,
  • "Self-assembly of DNA nanomechanical devices." 2016,
  • "Engineering DNA origami motion and structural dynamics." 2016,
  • "Mechanical Design of DNA nanostructures and measurement devices." 2015,
  • "Self-assembly of DNA nanodevices." 2015,
  • "Mechanical Design of DNA-based measurement devices." 2016,
  • "DNA nanomechanical devices for molecular and cellular applications." 2016,
  • "Dynamic Biomolecular Interactions in DNA Origami Design.”." 2012,
  • "Probing the Structural Diversity of Yeast Amyloid Fibers with Optical Tweezers." 2008,
  • "B Lymphocyte Membrane Reservoir Mechanics." 2008,
  • "An Elastica Approximate for Fibers and Fibrous Networks." 2008,
  • "Mechanics at Biology’s Length Scales." 2008,
  • "Programming Biological Self-Assembly for the Design of Nanoscale Engineering Tools and Materials." 2011,
  • "Design of Mechanically Functional DNA Origami Nanostructures." 2014,
  • "DNA-based mechanical devices to probe molecular and cellular interactions." 2014,
  • "Programming Biological Self-Assembly for the Design of Nanoscale Engineering Tools.”." 2011,
  • "Engineering with Biology’s Building Blocks." 2013,
  • "Controllable DNA nanostructures for delivering and detecting cellular signals.”." 2013,
  • "Mathematical Modeling of Manufacturing Processes." 2005,
  • "Optimization and Analysis of Variability in Injection Molding.”." 2006,
  • "Programming Biological Self-Assembly for the Design of Nanoscale Engineering Tools." 2011,
  • "Programming Biological Self-Assembly for the Design of Nanoscale Engineering Tools and Materials.”." 2012,
  • "Engaging undergraduates in Designing and Building Biomolecular Systems." 2014,
  • "Modifying DNA origami structure and function using single-stranded DNA." 2014,
  • "Mechanically Functional DNA origami Nanostructures." 2014,
  • "Designing Mechanical Dynamics of DNA origami Nanostructures." 2014,
  • "Mechanical Design of DNA-based probes and sensors." 2015,
  • "DNA-based nanomechanical devices." 2015,
  • "Programming dynamics of DNA origami." 2016,
  • "Mechanical Design of DNA-based sensors, tools, and delivery vehicles." 2015,

Papers in Proceedings

2016

  • "Pseudorigid-Body Models of Compliant DNA Origami Mechanisms." in 39th ASME Mechanisms and Robotics Conference. (10 2016).

2014

  • Qirui Fan, Gauri Nabar, Carl Miller, Carlos Castro, Jessica Winter "Photo-switchable quantum dots based on reversible FRET." in SPIE Photonics West. (2 2014). 89540D - 89540D.

2013

  • "REVERSE ENGINEERING THE STRUCTURE AND FUNCTION OF THE ALLEGHENY MOUND ANT NECK (INSECTA, HYMENOPTERA, FORMICA, EXSECTOIDES)." in ASME International Mechanical Engineering Congress and Exposition. (1 2013).

2012

  • HJ Su, Carlos E Castro, Alex E Marras, Michael Hudoba "Design and fabrication of DNA origami mechanisms and machines." in ASME International conference on reconfigurable mechanisms and robots. (9 2012). 487-500 - 487-500.
  • Marras, AE, Zhou, L, Su, HJ, Castro, CE "Design of DNA Origami Machines and Mechanisms." JOURNAL: "ASME Proceedings - Micro- and Nano-Systems Engineering and Packaging." in ASME IMECE. (11 2012). 301-309 - 301-309.