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Carlos Castro

  • Assistant Professor, Mechanical & Aerospace Engr
  • 201 W 19th Ave
    E328 Scott Lab
    Columbus, OH 43210
  • 614-292-2662


Research interests include:

  • Utilize engineering approaches combined with nanotechnology and biophysics experimental tools
  • Characterize and model the physical properties and behaviors of complex biological systems
  • Goal to establish an array of functional DNA nanotechnology-based tools
  • Goal to reverse engineer the design of biological systems that exhibit remarkable mechanical properties


  • 2014-2019

    National Science Foundation Career Award. .

  • 2015

    Michael J Moran Award for Teaching Excellence. .

  • 2013

    Pi Tau Sigma Above and Beyond Award. .

  • 2009-2011

    Alexander von Humboldt Post-doctoral Fellow. .

  • 2008

    Outstanding research award. .

  • 2005-2006

    Presidential Fellowship. .

Journal Articles




  • Zhou,Lifeng*; Marras,Alexander,E*; Su,Hai-Jun; Castro,Carlos,E, 2014, "DNA Origami Compliant Nanostructures with Tunable Mechanical Properties." ACS Nano 8, no. 1, 27 - 34.
  • Gupta,C*; Liao,W-C; Gallego-Perez,D; Castro,C,E; Lee,L,J, 2014, "DNA translocation through short nanofluidic channels under asymmetric pulsed electric field." Biomicrofluidics 8, no. 2, 024114 -


  • JM Tam, CE Castro, RJW Heath, MK Mansour, ML Cardenas, RJ Xavier, MJ Lang, JM Vyas, 2011, "Use of an optical trap for study of host-pathogen interactions for dynamic live cell imaging." Journal of Visualized Experiments 53, pii: 3123 -
  • Jungmann, R., Scheible, M., Kuzyk, A., Pardatscher, G., Castro, C.E., and Simmel F.C., 2011, "DNA origami-based nanoribbons: assembly, length distribution, and twist." Nanotechnology 22, no. 27, 275301 -
  • Castro, C.E., Dong, J., Lindquist, S., Boyce, M.C., Lang, M.J., 2011, "Physical Properties of Polymorphic Prion Proteins." Biophysical Journal 101, no. 2, 439 - 448.


  • Tam, J., Castro, C.E., Heatsh, R.J., Cardenas, M.J., Xavier, R., Lang, M.J., Vyas, J.M., 2010, "Control and Manipulation of Pathogens with an Optical Trap for Live Cell Imaging of Intercellular Interactions." PLoS One 5, no. 12, e15215 -
  • Lee,Hyungsuk; Castro,Carlos,E; Shin,Yongdae; Kamm,Roger,D; Lang,Matthew,J, 2010, "Active Stochastic Microrheology using Optical Tweezers." Biophysical Journal 98, no. 3, 592A - 592A.
  • Dong, J., Castro, C.E., Boyce, M.C., Lang, M.J., and Lindquist, S., 2010, "Optical trapping with high forces reveals unexpected behaviors of prion fibrils." Nature Structural & Molecular Biology 17, no. 12, 1422 - U49.


  • Kim, S.T., Takeuchi, K., Zhen-Yu, J.S., Touma, M., Castro, C.E., Fahmy, A., Vibhuti, D., Kappes, D., Lang, M.J., Wagner, G., Reinherz, E., 2009, "The alpha betaT cell receptor is an anisotropic mechanosensor." Journal of Biological Chemistry 284, no. 45, 31028 - 31037.





  • "Engaging undergraduates in Designing and Building Biomolecular Systems." 2014, Presented at Physics Research & Education Gordon Conference, US|USA
  • "Modifying DNA origami structure and function using single-stranded DNA." 2014, Presented at Foundations of Nanotechnology, Snowbird, US|USA
  • "Mechanically Functional DNA origami Nanostructures." 2014, Presented at World Congress of Biomechanics, Boston, US|USA
  • "Designing Mechanical Dynamics of DNA origami Nanostructures." 2014, Presented at American Chemical Society Midwest Regional Meeting, Pittsburgh, US|USA
  • "DNA origami tools for chromatin for the study of chromatin structure and dynamics." 2015, Presented at ASME Nanoengineering for Medicine and Biology 2015, Minneapolis, MN, US|USA
  • "Mechanical Design of DNA-based probes and sensors." 2015, Presented at Wyss Institute for Biologically Inspired Engineering Research Seminar, Boston, US|USA
  • "Mechanical Design of DNA Nanostructures for Physical Measurements." 2015, Presented at Society of Engineering Science Annual Meeting, College Station, US|USA
  • "Self-assembly of DNA nanomechanical devices." 2016, Presented at University of Illinois Urbana Champaign Mechanical Engineering Seminar, Urbana Champaign, US|USA
  • "Engineering DNA origami motion and structural dynamics." 2016, Presented at 10 years of DNA origami symposium, Pasadena, US|USA
  • "Mechanical Design of DNA nanostructures and measurement devices." 2015, Presented at Massachusetts Institute of Technology Mechanical Engineering Department Colloquium, Boston, US|USA
  • "DNA-based nanomechanical devices." 2015, Presented at University of Texas, Austin NASCENT center seminar series, Austin, US|USA
  • "Programming dynamics of DNA origami." 2016, Presented at The Molecular Programming Project Annual Workshop, Seattle, US|USA
  • "Mechanical Design of DNA nanostructures and measurement devices." 2015, Presented at University of California San Diego Nanoengineering Department Seminar, San Diego, US|USA
  • "Mechanical Design of DNA-based sensors, tools, and delivery vehicles." 2015, Presented at Nationwide Children's Hospital Child Health Research Center Seminar, Columbus, US|USA
  • "Self-assembly of DNA nanodevices." 2015, Presented at National Academy of Science Arab-American Frontiers of Engineering, Jeddah, SA|SAU
  • "Engineering DNA origami motion and structural dynamics." 2016, Presented at Spiez CONVERGENCE, Spiez, CH|CHE
  • "Mechanical Design of DNA-based measurement devices." 2016, Presented at Princeton University Mechanical Engineering Seminar Series, Princeton, US|USA
  • "DNA nanomechanical devices for molecular and cellular applications." 2016, Presented at Kavli Frontiers of Science Symposium, Irvine, US|USA
  • "Mechanical Design of DNA Nanostructures and Devices." 2016, Presented at Air Force Research Laboratory Soft Matter Seminar, Dayton, US|USA

Papers in Proceedings


  • Zhou, L, Marras, AE, Castro, CE, Su, H-J "Pseudo-Rigid-Body Models of Compliant DNA Origami Mechanisms." JOURNAL: "ASME 2015 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference." in ASME International Design Engineering Technical Conference. (8 2015). V05BT08A041 -


  • Qirui Fan, Gauri Nabar, Carl Miller, Carlos Castro, Jessica Winter "Photo-switchable quantum dots based on reversible FRET." in SPIE Photonics West. Bellingham, (2 2014). 89540D -



  • HJ Su, Carlos E Castro, Alex E Marras, Michael Hudoba "Design and fabrication of DNA origami mechanisms and machines." in ASME International conference on reconfigurable mechanisms and robots. New York, (9 2012). 487 - 500.
  • Marras, AE, Zhou, L, Su, HJ, Castro, CE "Design of DNA Origami Machines and Mechanisms." JOURNAL: "ASME Proceedings - Micro- and Nano-Systems Engineering and Packaging." in ASME IMECE. (11 2012). 301 - 309.