Scott Labm E525
Scott Labm E525
201 W. 19th Ave.
Columbus, OH 43210
Programable DNA nanostructures for biomedical research
A key challenge in nanotechnology is the precise fabrication of complex nanostructures and nanodevices, which can be used as general platforms for basic science research (e.g. materials science, structural biology, molecular biology, etc.), and for practical applications. Owing largely to its programmable design strategies, nucleic acids self-assembly, and in particular DNA self-assembly, has emerged as a powerful approach in programming self-assembly of custom-designed intricate nanostructures and dynamic nanodevices.
The core mission of our lab (ke-lab.gatech.edu) is to develop novel self-assembly strategies to realize the full potential of DNA as a programable nanomaterial. Our recent works focus on making massive/complex static DNA nanostructures and dynamic DNA devices. We invented a modular assembly strategy for constructing complex 3D shapes with rationally designed shapes, by using short synthetic DNA oligos — “DNA bricks”. We also developed many dynamic DNA nanomachines that can perform a range of controlled motions at nanoscale. Recently, we have demonstrated prescribed, long-range information relay in artificial molecular arrays assembled from modular “DNA domino”: Once initiated at a few selected units, the transformation then propagates to neighboring units and eventually the entire array. Beyond sophisticated nanostructures and nanomachines, DNA nanotechnology has found increasing capabilities in many applications. Our most recent works include DNA-templated self-assembly of new functional nanomaterials, DNA-based nanoscale drug delivery systems for cancer treatment, DNA nanodevices for the interrogation of cellular force generation and cooperativity between T-cell receptor and co-receptors.
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