Seminar: 4D Organ Engineering to Develop Cellular Therapies for Treating Blood Cancers

Abstract

Dhvanit Shah's laboratory investigates methods to develop clinical-grade functional hematopoietic stem cells and blood lineages from patient-derived tissues for the treatment of blood and bone marrow cancers using state-of-the-art organ-in-a-dish, bio-inspired micro-electric-mechanical system fabrication, 4D-bioprinting, bio-inspired matrices, gene-editing, microfluidics, cell-engineering, nanotechnology, ex vivo mouse embryo and explant culture, as well as computational approaches. Shah's team has expertise in utilizing zebrafish, mice and human induced pluripotent stem cells  to clone and analyze novel genes and mechanisms important for hematopoietic stem cells biology and its use in improved therapies. He and his colleagues are currently investigating microenvironmental conditions that stimulates the endothelial emergence of hematopoietic stem cells and subsequent proliferation during fetal development. Shah's long-term vision is to develop multi-dimensional bioreactor to generate scalable, universally compatible, clinical-grade hematopoietic stem cells from skin graft to treat malignant or non-malignant blood and bone marrow disorders.

About the speaker

Coming soon.

Hosted by Prof. Vish Subramaniam.