Seminar: Additive Manufacturing of Polycaprolactone (PCL) Scaffolds and Endovascular Stents
Additive manufacturing (AM) technologies allow rapid and efficient production of custom-designed parts. However, optimization of the design, printing material characteristics and fabrication parameters, are usually required to insure desirable manufacturing results. The group's addittive manufacturing experience has been presented to the research group of product, process and production engineering (GREP) – University of Girona (Spain) with biomedical devices such as stents or tissue engineering scaffolds. The work to date focuses on the optimization and parameter selection for an open-source 3-D extrusion additive manufacturing device to manufacture Poly Ɛ-CaproLactone (PCL) scaffolds or PCL endovascular stents. PCL is biocompatible and nontoxic polymer, which has been used to fabricate scaffolds, including solid structures suitable for 3-D cancer cell culture. Scaffold cell culture has been shown to enhance the cancer stem cells population, related to tumour chemoresistance and recurrence after chemotherapy. Bioabsordable stents for endovascular use offer the potential to improve long-term patency by providing support just long enough for the artery to heal itself. Currently the stent industry primarily uses laser micro-cutting fabrication for metallic, non-resorbing stents. Nevertheless, polymer bioabsordable stents systems prepared by additive manufacturing techniques could be a better solution.
About the speaker
Joaquim de Ciurana holds a PhD in industrial engineering from UPC (1997). He has completed several postdoctoral stays at Rutgers, The State University of New Jersey; Cranfield University (UK); and Université du Québec à Trois-Rivières (Canada). At the University of Girona he has been a full professor of manufacturing process engineering since 2009. His research in product engineering, process and production at the University of Girona has resulted in more than 100 journal articles about design methodologies, planning of manufacturing processes, characterization of machining and additive manufacturing processes and design and prototyping of medical devices. He has also participated in writing 12 book chapters and has participated in 80 international and national conferences. In recent years he has led several research projects in the biomedical field, such as in designing new medical devices, manufacturing prototypes for the biomedical sector or improvement systems for cell culture in the field of tissue engineering. He also devotes special attention to the collaboration between the industrial sector and research, as noted by a November 2011 ASCAMM Technology Center award for scientific collaboration with corporate partners. He has promoted numerous collaboration agreements with companies to transfer knowledge to industry and apply the research that developed this new knowledge.
Hosted by Professor David Hoelzle.