Applied Physics Laboratory: Research
Research
Eddy Current Detection
Eddy current probe
The current treatment for localized tumors is surgical resection of cancerous tissue. The biggest challenge in this treatment method is the prevention of recurrence which is mainly caused by unsuccessfully removing all of the cancerous tissue. A surgeon has only visual and palpable cues to determine where the edge of a tumor is located. Our group is focused on developing an instrument to help in the detection of these margins. Our device uses eddy currents to detect surface and subsurface flaws in biological tissue, much like current eddy current detectors used in tubing inspection. With real-time intraoperative imaging of the tumor site, a surgeon will have additional information to make more informed decisions which will hopefully lead to a greater survival curve for patients with operable cancers.
Controlled Cell Migration
It has been well documented since the work of Dineur in 1892 that certain cells will migrate in the presence of a DC electric field. However, this method of directing cell movement requires physical contact and substantial strength of the electric field. Our work focuses on developing a non-contact method for directing electrotaxis. This method has applications in embryonic development, wound healing, and metastasis of cancer.
Wound Healing
We are interested in studying the mechanisms by which electric fields can accelerate or inhibit wound closure depending on method of application. Additionally our lab works on collaborative projects in the investigation of electric effects on bacterial infections in wounds.
Malaria Detection
Plasmodium falciparum is a parasite that causes malaria in humans. The current method of diagnosis of malaria is a "blood smear" which involves extraction of blood from the patient and looking at the blood under a microscope. Our goal is to develop a diagnostic method which is simple to use and does not require a trained pathologist.